Sufentanil Citrates Liquid

Sufentanil Citrates Liquid

Sufentanil citrate is a potent fentanyl analog evaluated primarily for use in opioid anesthesia It is a pure mu agonist that produces a typical opioid spectrum of effects

The main side effects of Sufentanil Citrates Liquid are trunk rigidity and prolonged respiratory depression At doses of 4 to 30 μg/kg, sufentanil produces hypnotic effects and suppresses most hemodynamic and hormonal responses to surgery without causing significant cardiovascular depression In this regard, sufentanil and fentanyl have clear advantages over morphine, meperidine and strong inhaled anesthetics Sufentanil acts faster and lasts longer than fentanyl.

The relatively high concentration of commercially available sufentanil injection would make it more practical than fentanyl injection for its intended application. The new drug will mainly be used in open-heart surgery and major surgery in patients with severe cardiovascular disease.

Sufentanil is a selective mu-opioid agonist that is 10 times more potent than fentanyl and over 1000 times more potent than morphine Sufentanil citrate is used as an analgesic and anesthetic.

There are some differences in the activity and selectivity of μ-opioid agonist analgesics Receptor internalizing agonists such as β-endorphin, methadone, fentanyl, and sufentanil have been shown to induce NADH/NADPH-mediated reactive oxygen species (ROS) synthesis via a pathway of phospholipase D-dependent signaling, while morphine isoagonists do not induce receptor endocytosis. Activates the synthesis of ROS. In another report, memeridine, remifentanil and tramadol interact with alpha(2)-adrenergic receptors, but not sufentanil.