Sufentanil Citrates Liquid


Sufentanil is a mu-opioid selective agonist, 10 times more potent than fentanyl, over 1000 times more potent than morphine. Sufentanil citrate is used as an analgesic and anesthesia adjunct. There are some differences in activity and selectivity among the mu-opiate agonist analgesics. Receptor-internalizing agonists like beta-endorphin, methadone, fentanyl, and sufentanil have been found to induce NADH/NADPH-mediated reactive oxygen species (ROS) synthesis via Phospholipase D-dependent signaling pathways whereas agonists like morphine that do not induce receptor endocytosis failed to activate ROS synthesis. In another report meperidine, remifentanil and tramadol were found to interact with alpha(2)-adrenoceptors, whereas sufentanil did not.